Synthesis and structure confirmation of 2,4-disubstituted thiazole and 2,3,4-trisubstituted thiazole as thiazolium bromide salts
نویسندگان
چکیده
منابع مشابه
Synthesis and applications of 2,4-disubstituted thiazole derivatives as small molecule modulators of cellular development.
Understanding how the structure of molecules relates to their function and biological activity is essential in the development of new analogues with targeted activity. This is especially relevant in mediating developmental processes in mammalian cells and the regulation of stem cell differentiation. In this study, thiazole-containing small molecules were synthesised and investigated for their a...
متن کاملSynthesis of New Thiazole, Bithiazolidinone and Pyrano[2,3-d ]thiazole Derivatives as Potential Antimicrobial Agents
In an attempt to find a new class of antimicrobial agents, a series of thiazole derivatives containing furan moiety 3, 7, 8a,b, 10a-c and 12 were prepared via the reaction of 2-cyano-N-(furan-2-ylmethyl)acetamide (1) with phenyl isothiocyanate and α-halocarbonyl compounds. Also, many bithiazolidinone and pyranothiazole derivatives were synthesized through interaction of thiazolidinone 7 with ap...
متن کاملThiazole and Oxazole Alkaloids: Isolation and Synthesis
Thiazoles, oxazole and their corresponding reduced derivatives, thiazolines and oxazolines, are found in marine sources exhibiting significant biological activities. The isolation, synthetic, and biological studies of these natural products, covering literature from January 2007 to June 2010, are summarized.
متن کاملSynthesis of Thiazole Derivatives via Multicomponent Reaction of Tetramethyl thiourea using Water as a Safe Solvent
An efficient synthesis of 1,3-thiazole drivatives is described via a three component reaction isothiocyanates, tetramethyl thiourea and ethyl bromopyruvate.
متن کاملSynthesis and cytotoxicity evaluation of thiosemicarbazones and their thiazole derivatives
The aims of this study were to synthesize a series of thiosemicarbazones and their thiazole derivatives, to investigate their cytotoxic activity against three human cancers and normal (Vero cells) cell lines, and to evaluate the pro-apoptotic potential of the most active compounds. Materials and Methods: The thiosemicarbazones were obtained by reacting an aromatic aldehyde with thiosemicarbazid...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Monatshefte für Chemie - Chemical Monthly
سال: 2020
ISSN: 0026-9247,1434-4475
DOI: 10.1007/s00706-020-02640-3